IgA Production and Purification
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IgA production and purification are fundamental processes in the study and application of immunoglobulin A (IgA), a critical antibody class that plays a vital role in mucosal immunity. IgA is the predominant antibody found in mucous membranes, such as those lining the respiratory and gastrointestinal tracts, where it acts as the first line of defense against pathogens. In research and clinical applications, IgA production involves utilizing cell cultures or recombinant DNA technology to generate sufficient quantities of this antibody. Following production, purification techniques, such as affinity chromatography, are employed to isolate IgA from other proteins and impurities, ensuring high purity and activity. Understanding and improving IgA production and purification processes are essential for developing IgA-based therapeutics and vaccines, particularly in preventing infections at mucosal surfaces. |
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